Ko te HPMC Hydroxypropyl methylcellulose, e mohiotia ana ko te hypromellose, ko tetahi o nga ethers whakauru kore-ionic cellulose.He waerau hangarua, hohekore, viscoelastic e whakamahia nuitia ana hei whakahinuhinu i roto i nga mahi ophthalmology, hei whakangao, hei awhina ranei i nga rongoa waha.
Ingoa Hua Hydroxypropyl methyl cellulose(HPMC)
Ētahi atu ingoa Hydroxypropyl methylcellulose,MHPC, methyl Hydroxypropyl cellulose
Nama Rehita CAS 9004-65-3
Te ahua o te ma, te paura kirikiri, kirikiri ranei
whakaahuatanga haumaru S24/25
Ko nga ahuatanga o te tinana me te matū
Te ahua: he ma, tata ma ranei te paura kirikiri, kirikiri ranei
Pūmautanga: He muramura te totoka me te kore hototahi ki nga waikura kaha.
Granularity;Ko te tere haere o te 100 mata he nui ake i te 98.5%.Ko te tere haere o nga kanohi 80 he 100%.Rahi motuhake o te rahi matūriki 40 ~ 60 mata.
Te pāmahana warowaihā: 280-300 ℃
Kiato ahua: 0.25-0.70g/cm3 (te nuinga o te 0.5g/cm3), te taumahatanga motuhake 1.26-1.31.
Te huringa tae o te pāmahana: 190-200 ℃
Te mānukanuka mata: 42-56dyne/cm i roto i te 2% wairewa wai
Te wairewa: te wairewa i roto i te wai me etahi whakarewa, penei i te wahanga tika o te waiwaro/wai, propanol/wai, me etahi atu. He mahi mata te wairewa wai.Ko te maamaatanga teitei, te pumau o te mahi, he rereke nga whakaritenga o te pāmahana kiri hua, he rereke te rereke me te pokey, te iti o te pokey, te nui ake o te whakarewatanga, he rereke nga whakaritenga o te mahi HPMC, ko te otinga HPMC i roto i te wai kaore e pa ki te wai. uara pH.
I heke te mahi mata o te HPMC i te hekenga o te methoxyl ihirangi, te pikinga o te ira gel me te heke o te wairewa wai.
Kei te HPMC hoki te kaha o te matotoru, te tote i te iti o te paura pungarehu, te pumau o te pH, te pupuri wai, te pumau o te rahi, te hanga kiriata pai, me te whānuitanga o te aukati ki te whaariki, te mararatanga me nga ahuatanga honohono.
Nga tikanga whakaputa
Ko te cellulose miro parakore ka tukuna ki te rei i te 35-40 ℃ mo te haurua haora, ka pehia, ka pakaruhia te cellulose me te pakeke ki te 35 ℃, na reira ko te tohu polymerization toharite o te muka alkali ka riro i roto i te awhe e hiahiatia ana.Hoatuhia te muka kawakore ki roto i te ketere whakamaarama, taapirihia te propylene oxide me te mewaro pūhaumāota, ka whakamahana i te 50-80 ℃ mo te 5h, ko te pehanga teitei kei te 1.8mpa.Kātahi ka tāpirihia te nui o te waikawa pūmāota me ngā rauemi horoi waikawa oxalic ki roto i te wai wera 90 ℃ hei whakanui ake i te rōrahi.I te iti iho i te 60% te ihirangi wai i roto i te rauemi, ka maroke ki te iti iho i te 5% e te rere o te hau wera i te 130 ℃.Ka mutu, ka tukitukia te hua kua oti, ka taraihia ma te 20 mata.
Tikanga whakakore
1, ka taea te taapiri i nga tauira katoa ki te rauemi ma te tikanga whakaranu maroke.
2, Me tika te taapiri atu ki te otinga wai pāmahana noa, he pai ki te whakamahi i te whakamararatanga wai matao, i muri i te taapiri i roto i te 10-90 meneti kia matotoru.
3. Ka taea te whakakore i nga tauira noa i muri i te ranu me te marara ki te wai wera me te taapiri i te wai matao i muri i te whakaoho me te whakamatao.
4. I te wa e rewa ana, mena ka puta te ahuatanga o te whakahiatotanga, na te mea kaore i te rawaka te whakaranu, ka taapiri tika ranei nga tauira noa ki te wai matao.I tenei wa, me tere te whakaoho.
5. Mena ka puta nga mirumiru i te wa e whakakorehia ana, ka taea te tango ma te tu mo te 2-12 haora (ko te waa motuhake ka whakawhirinaki ki te rite o te otinga) ma te whakamaarama ranei me te pehanga, ma te taapiri ranei i te nui o te kaihoko whakakore.
Ka whakamahia e HPMC
Ka whakamahia hei whakamaroke, hei whakamararatanga, hei here, hei whakauru, hei whakakikorua i te hinu, hei whakakii, hei emulsifier me te whakapumau i roto i te umanga pueru.Ka whakamahia ano hoki i roto i te kapia waihanga, te petrochemical, te karaima, te pepa, te hiako, te rongoa, te kai me te whakapaipai me etahi atu ahumahi.
Ko te kaupapa matua
1, ahumahi hanga: rite sima kumete parepare pupuri wai, retarder kumete ki te papu.I roto i te raima, te gypsum, te paura putty me etahi atu mea hanga whare hei whakapiri, te whakapai ake i te daub me te whakaroa i te wa mahi.Ka whakamahia mo te whakapiri i te taera karaima, te mapere, te whakapaipai kirihou, te whakapiri i te kaihoko whakapakari, ka taea tonu te whakaiti i te inenga ciment.Ko te mahi pupuri wai a HPMC ka kore te slurry i muri i te tono ka maroke tere me te kapiti, ka whakarei ake i te kaha i muri i te whakapakeke.
2, hanga uku: whakamahia whānuitia hei whakapiri i roto i te hanga hua uku.
3, ahumahi whakakikorua: i roto i te ahumahi paninga rite te thickener, dispersant me stabilizer, i roto i te wai whakarewa organic ranei i te wairewa pai.Hei tango peita.
4, waituhi tā: i roto i te ahumahi mangumangu rite te thickener, dispersant me stabilizer, i roto i te wai whakarewa organic ranei i te wairewa pai.
5, kirihou: mo te hanga i te kaihoko tuku, ngawari, whakahinuhinu, etc.
6, PVC: Ko te hanga PVC hei dispersant, whakatārewatanga polymerization faaineineraa o pvc pŭpŭ tauturu matua.
7, ahumahi ho'oraa: rauemi paninga;rauemi membrane;Ko nga rauemi polymer e whakahaere ana i te reiti mo nga whakaritenga tuku-patua;Kaitohu whakau;He awhina whakatarewa;Pipiri papa;Whakanuia te goo
8, Ētahi atu: whakamahia whānuitia hoki i roto i te hiako, ahumahi hua pepa, hua me te tiaki huawhenua me te ahumahi pueru.
Tono ahumahi motuhake
Te ahumahi hanga
1, kumete ciment: te whakapai ake i te marara o te sima – onepu, nui te whakapai ake i te plasticity me te pupuri wai o te kumete, ki te ārai kapiti i te pānga, ka taea e whakarei ake i te kaha o te sima.
2, sima taipa uku: whakapai ake i te plasticity o te kumete tile uku, te pupuri wai, te whakapai ake i te tānga kāpia o te tira uku, ārai paura.
3, asbestos me etahi atu paninga whakaahuru: ano he kaihoko whakatārewatanga, he kaihoko whakapai ake, engari he pai ake ano te turanga o te reera kapia.
4, gypsum slurry: whakapai ake i te pupuri i te wai me te mahi, te whakapai ake i te piri o te turanga.
5, sima tahi: tāpiri i roto i te papa gypsum ki te sima tahi, whakapai fluidity me te pupuri wai.
6, taherapa putty: whakapai ake i te fluidity me te wai pupuri o te kapia taherapa putty hāngai.
7, kumete: hei whakakapi mo te whakapiri taiao, ka taea te whakapai ake i te pupuri wai, te whakapai ake i te reera kapia me te turanga.
8, paninga: rite te plasticizer o te taherapa paninga, he wahi i roto i te whakapai ake i te mahi whakahaere me te fluidity o paninga me te putty paura.
9, paninga rehu: ki te ārai sima tawhetawhe ranei rehu mapu anake rauemi whakakī totohu me te whakapai ake i te rere me te rehu kurupae whakairoiro whai pānga pai.
10, ciment, gypsum hua tuarua: rite sima – asbestos me etahi atu rauemi waipēhi pēhi niao here, whakapai ake i te wai, ka taea te tiki hua niao kākahu.
11, taiepa muka: no te mea o te anti-enzyme pānga anti-huakita, i te mea he whai hua te here o te taiepa onepu.
12, etahi atu: ka taea te whakamahi hei kumete angiangi moata me te mahi moata kaiwhakahaere o te kaihoko pupuri mirumiru.
Te ahumahi matū
1, vinyl pūhaumāota, vinyl polymerization: rite polymerization whakatārewa stabilizer, dispersant, ki te waipiro vinyl (PVA) hydroxypropyl cellulose (HPC) me te taea te whakahaere i te tohatoha o te ahua matūriki me te matūriki.
2, piri: rite pepapātū whakapiringa, hei utu o māngaro e taea te nuinga o te whakamahi ki te vinyl acetate taherapa paninga.
3. Pesticide: ka tapirihia ki nga ngarara me nga otaota, ka taea te whakapai ake i te paanga o te piri i te wa e pupuhi ana.
4, taherapa: whakapai ake i te whakaehunga whakaehunga o te uku, te rapa styrene butadiene (SBR) te whakakao i te taherapa.
5, hei here: hei pene, he kiripiri hei whakapiri.
Te ahumahi whakapaipai
1. Shampoo: whakapai ake i te viscosity me te pumau o nga mirumiru o te shampoo, te hopi me te hopi.
2. Toothpaste: Whakapai ake i te rere o te toothpaste.
Te ahumahi kai
1, citrus kēne: aukati i roto i te tiaki e tika ana ki te pirau o te karaka glycosides me te kāhuarau whitening ki te whakatutuki i te hou.
2, hua matao hua: tāpiri i roto i te tomairangi hua, reo tio, kia pai ake te reka.
3, ranu: rite ranu, ranu tōmato whakaehunga pūmau mātanga thickening ranei.
4, wai matao paninga glazing: whakamahia mo te rokiroki ika tio, ka taea te ārai discoloration, whakaiti kounga, ki te methyl cellulose hydroxypropyl methyl cellulose otinga whakakikoruatia glazing ranei, a ka whakatotoka i runga i te tio.
5, te whakapiringa o nga pire: i te mea ko te whakapiringa o nga pire me nga pire, he pai te hononga me te tiango (tere ka memeha ka marara ina tango).
Te ahumahi rongoa
1. Te whakakikorua: ka hangaia te kaihoko whakakikorua ki te otinga whakarewa pararopi, ki te wairewa wai ranei mo nga papa, ina koa mo nga matūriki i hangaia i te paninga rehu.
2, pōturi iho kaihoko: 2-3 karamu ia ra, ia wa 1-2G inenga, i roto i te 4-5 ra ki te whakaatu i te pānga.
3, rongoa kanohi: no te mea te pēhanga osmotic o hydroxypropyl methyl cellulose wairewa wai he rite ki te roimata, na he iti ki te kanohi, tāpiri rongoa kanohi, rite te whakahinuhinu ki te whakapā atu te kanohi kanohi.
4, kaihoko gelatinous: rite te rauemi turanga o gelatinous rongoā waho hinu hinu ranei.
5, impregnating tarukino: rite te māngai thickening, māngai pupuri wai.
Te ahumahi oumu
1, rauemi hiko: rite uku hiko denser, bauxite ferrite autō pēhanga niao whakapiringa, ka taea te whakamahi ki te 1.2-propylene glycol.
2, glaze: whakamahia hei karaera uku me te porcelain ki te tohu, ka taea te whakapai ake i te hononga me te mahi.
3, kumete whakaahuru: taapirihia ki roto i te kumete whakamaarama, i nga mea oumu maka ranei, ka taea te whakapai ake i te kirihou me te pupuri wai.
Ētahi atu ahumahi
1, muka: rite tā whakapiri waikano mō pigments, tae ngahere boron, tae tote e hāngai ana, tae pueru, i roto i te tua, i roto i te tukatuka ripple kapok, ka taea te whakamahi ki te kapia whakapakeke wera.
2, pepa: whakamahia mo te waro pepa hiako gluing me te tukatuka hinu me etahi atu waahanga.
3, hiako: rite te whakahinuhinu whakamutunga ranei te whakamahi piri.
4, waituhi-waituhi: tāpiri ki te wai-waituhi waituhi, mangumangu, rite thickening māngai, kiriata hanga kaihoko.
5, tupeka: hei whakapiringa o te tupeka hangarua.
Paerewa Pharmacopoeia
Te puna me te ihirangi
Ko tenei hua he 2- hydroxypropyl ether methyl cellulose.Ka taea te wehea te Hydroxypropyl methylcellulose ki nga momo e wha e ai ki te ihirangi o te methoxy me te hydroxypropyl, ara 1828, 2208, 2906, 2910. Ko nga ihirangi o ia methoxy kua whakakapia (-OCH3) me te hydroxypropoxy (-OCH2ChohCH3) me ū ki nga waahanga kua piri. tepu.
huru
Ko tenei hua he ma, he ahua-ma ranei, he kirikiri, he paura maramara ranei;Karekau.
Ko tenei hua he tata kore e rewa i roto i te waiwaro anhydrous, ether me te acetone;Te pupuhi i roto i te wai matao ki te hanga i te wairewa colloid maataa, paku puhoi ranei.
Hei tautuhi
(1) Tangohia 1g o te hua, whakamahana 100mL o te wai (80 ~ 90 ℃), whakaohokia tonu, whakamatao i roto i te pati hukapapa, ka hanga he wai piri;Kuhua te 2mL o te wairewa ki roto i te ipuipu, me ata taapirihia te 1mL o te wairewa waikawa pungatara anthracene 0.035% ki te taha o te pakitara ngongo, waiho mo te 5 meneti, ka puta he mowhiti puru-matomato ki te atanga i waenganui i nga wai e rua.
(2) Ka ringihia te rahinga tika o te wai kakariki i raro i te tohu (1) ki te pereti karaihe.I muri i te whakaetonga o te wai, ka hangaia he paparanga o te kiriata uaua.
taki
1, ph
I muri i te whakamatao, whakatikahia te otinga ki te 100g me te wai ka whakaoho kia rewa katoa.Whakatauhia i runga i te ture (Appendix ⅵ H, Part II of Pharmacopoeia, 2010 edition).Ko te uara PH kia 5.0-8.0.
2, pokey
2.0% (g/g) whakatārewatanga i whakaritea ma te tango i te 10.0g o te hua me te taapiri i te 90 ℃ te wai kia 500.0g te taumaha o te tauira me te wai hei hua maroke.I whakakorikoria katoatia te whakatārewatanga mo te 10 meneti kia marara noa nga matūriki me te makuku.I whakamataohia te whakatārewatanga i roto i te pati hukapapa me te whakaoho tonu mo te 40 meneti i te wa e whakamahana ana.Ko te rango potaka takahuri hurihuri kotahi (ka taea te whakamahi i te ndJ-1 mo nga tauira me te pokey iti iho i te 100Pa·s, me te NDJ-8S ka taea te whakamahi mo nga tauira me te pokey nui ake i te rite ranei ki te 100Pa·s, me etahi atu viscosimeter whai tohu) i whakamahia i te 20 ℃ ± 0.1 ℃, i whakatauhia i runga i te ture (te tikanga tuarua o ⅵ G i roto i te taapiri II o Pharmacopoeia 2010 putanga).Mēnā he iti iho i te 600mPa·s te pōkākā kua tapaina, me 80% ~ 120% o te pōkākā kua tapaina;Mēnā he nui ake, he ōrite rānei ki te 600mPa·s te pōkākā kua tapaina, me 75% ki te 140% o te pōkākā kua tapaina.
3 He matū kore whakarewa i te wai
Tangohia 1.0g o te hua, hoatu ki roto i te ipurau, tāpirihia he 100mL wai wera i te 80-90 ℃, pupuhi mo te 15 meneti, whakamatao ki roto i te kaukau tio, tāpirihia te 300mL wai (mehemea e tika ana, whakanuia te rōrahi o te wai kia tika. whakarite kia tātarihia te otinga), ka oho katoa, tātarihia ma te kore.1 ipu karaihe whakarewa poutū kua whakamaroke ki te taumaha tonu i te 105 ℃, ka horoi i te ipurau ki te wai.I tātarihia te wai ki roto i te ipu karaihe whakarewa poutū i runga ake nei, ka whakamarokehia ki te taumaha tonu i te 105 ℃, me te toenga kaore e neke ake i te 5mg (0.5%).
4 Te mate taimaha maroke
Tangohia tenei hua ka whakamaroke i te 105 ℃ mo nga haora 2, a ko te mate taimaha kaua e neke ake i te 5.0% (Appendix ⅷ L, Part II, Pharmacopoeia 2010 putanga).
5 Te tahu toenga
Tangohia te 1.0g o tenei hua ka tirohia kia rite ki te ture (Appendix ⅷ N, Part II of pharmacopoeia 2010 edition), a ko te toenga e kore e neke ake i te 1.5%.
6 whakarewa taumaha
Tangohia te toenga e toe ana i raro i te toenga maramara, tirohia kia rite ki te ture (ko te tikanga tuarua o te Tāpiritanga ⅷ H o te wahanga tuarua o te putanga 2010 o pharmacopoeia), kei roto nga konganuku taumaha kaua e neke atu i te 20 nga wahanga mo ia miriona.
7 tote arsenic
Tangohia 1.0g o tenei hua, tāpiri 1.0g konupūmā waihā, uru, tāpiri wai ki te oho riterite, maroke, tuatahi ki te ahi iti ki te warohia, a ka i te 600 ℃ ki te tahu tino pungarehu, mātao, tāpiri 5mL waikawa pūmāota me te 23mL wai. ki te memeha, tirohia kia rite ki te ture (2010 putanga o pharmacopoeia ii Appendix ⅷ J tikanga tuatahi), kia ū ki nga tikanga (0.0002%).
Te whakatau ihirangi
1, methoxyl
Ko te Methoxy, te ethoxy me te hydroxypropoxy (te taapiri VII F, Part II, 2010 Edition of Pharmacopoeia) i whakatauhia.Mēnā ka whakamahia te tikanga tuarua (tikanga rōrahi), tangohia te hua, kia tika te pauna me te ine i runga i te ture.Ko te nui methoxy ine (%) ka tangohia mai i te hua o te nui hydroxypropoxy (%) me te (31/75×0.93).
2, hydroxypropoxy
Ko te Methoxy, te ethoxy me te hydroxypropoxy (te taapiri VII F, Part II, 2010 Edition of Pharmacopoeia) i whakatauhia.Mena ka whakamahia te tikanga tuarua (te tikanga rōrahi), tangohia te hua mo te 0.1g, kia tika te pauna, whakatauhia i runga i te ture, ka whiwhi.
Pharmacology and toxicology
Ko te Hydroxypropyl methyl cellulose he waahanga o te cellulose methyl me tetahi waahanga o te hydroxypropyl ether, ka taea te rewa i roto i te wai matao hei hanga i te otinga viscous, ona taonga me ona roimata i roto i nga matū viscoelastic (te nuinga o te mucin) e tata ana, no reira, ka taea te whakamahi hei hangai. roimata.Ko te tikanga o te mahi ko te polymer e piri ana ki te mata o te kanohi na roto i te adsorption, ka peehia te mahi a te mucin conjunctival, na reira ka pai ake te ahua o te whakaheke mucin ocular me te whakanui ake i te roanga o te pupuri kanohi i te ahua o te whakaheke roimata.Ko tenei whakaurunga he mea motuhake mai i te pokey o te otinga, na reira ka taea te whakamakuku pumau ahakoa mo nga otinga pokey iti.I tua atu, ka piki ake te makuku o te kao ma te whakaiti i te Koki whakapiri o te mata o te mata ma.
pharmacokinetics
Kaore he korero mo te rongoa rongoa mo te whakamahinga o tenei hua.
tohu
Whakamakuku i nga kanohi ki te iti o te hunanga roimata me te whakakore i te mamae o te kanohi.
Whakamahinga
Ka taea e nga pakeke me nga tamariki te whakamahi.1-2 pata, e toru nga wa ia ra;Ka rite ranei ki te whakahau a te taote.
Ko nga tauhohenga kino ka whakatika i te korero
I roto i nga keehi onge, ka raru te kanohi penei i te mamae o te kanohi, te tirohanga rangirua, te paheketanga o te conjunctival tohe, te irirangi kanohi ranei.Mena ka kitea nga tohu o runga ake nei, ka mau tonu ranei, mutu te whakamahi i te tarukino ka haere ki te hohipera ki te tirotiro.
tabu
Contraindicated i roto i te hunga mate pāwera ki tenei hua.
Nga take hei aro
1. Kaua e pa ki te upoko pounamu maturuturu ki te kamo me etahi atu papanga kia kore ai e poke
2. Tena koa kia kore e taea e nga tamariki te hua
3. Kotahi marama i muri i te whakatuwheratanga o te pounamu, kaore e pai ki te whakamahi tonu.
4. Te rongoa mo nga wahine hapu me te whakauu: kaore i kitea he ripoata mo te kino o te whanautanga me etahi atu raruraru na te HYDROXYpropyl cellulose i roto i te tinana o te tangata;Karekau he tauhohenga kino i korerotia i roto i nga kohungahunga i te wa e whakawhanau ana.Na reira, karekau he whakamaarama motuhake mo nga wahine hapu me te u.
5. Te rongoa mo nga tamariki: ka whakatauritea ki etahi atu roopu reanga, ko te hydroxypropyl methylcellulose i roto i nga tamariki kaore e nui ake nga tauhohenga kino.Na reira, ka taea e nga tamariki me nga pakeke te whakamahi i tenei hua kia rite ki te mahere kotahi.
6, te rongoa mo te hunga tawhito: ko te whakamahinga o te hydroxypropyl methylcellulose i roto i nga turoro pakeke, ka whakatauritea ki etahi atu reanga pakeke, kaore he rereke o nga paanga o te taha me etahi atu raruraru.Na reira, ko te rongoa mo nga turoro kua koroheketia kaore he contraindication motuhake.
7, rokiroki: rokiroki rangi.
Te mahi haumaru
Morearea hauora
He haumaru tenei hua me te kore-paitini, ka taea te whakamahi hei taapiri kai, kaore he wera, kaore he pawera ki te kiri me te paanui mucous membrane.Ko te tikanga he haumaru (FDA1985).Ko te kai e whakaaetia ana ia ra ko te 25mg/kg (FAO/WHO 1985).Me mau nga taputapu tiaki i te wa e mahi ana.
Te paanga o te taiao
A ape i te parahanga hau na te rere o te puehu.
Nga morearea a-tinana me te matū: karohia te pa atu ki nga puna ahi, me te karo i te hanga i te nui o te puehu i roto i te taiao kati hei aukati i nga aitua pahū.
Ko nga taonga toa kua tukuna
Kia tupato ki te tiaki i te ra mai i te ua me te makuku, karohia te ra tika, hiri ki te wahi maroke.
Te wa haumaru
S24/25: Kaua e pa ki te kiri me nga kanohi.
A ape i te pa ki te kiri me nga kanohi.
Wā tuku: Tihema-02-2021